As the pandemic spreads, organized crime has been adapting to changing illicit market drivers. In Africa, increased border restrictions have impacted human-smuggling routes in the Sahel and the price of heroin in East and Southern Africa. Cocaine shipments from Latin America to West Africa are suspected of having restarted. In South Africa and Kenya, scammers have been exploiting fears and misinformation for profit. Anticipating opportunities for organized crime, particularly where security vulnerabilities already exist, will require building community support and depriving criminal groups of their legitimacy.